Common side effects can include:
skin irritation
burning
redness
dryness
pain
swelling
tenderness
scaling
peeling (exfoliation)
rash
changes in skin color at the site of application, or other local reactions
eye irritation (e.g., stinging, watering)
trouble sleeping
irritability
temporary hair loss
abnormal taste in the mouth
More serious side effects can also include:
stomach or abdominal pain
bloody diarrhea
vomiting
signs of infection (e.g., fever, chills, persistent sore throat)
easy bruising or bleeding
mouth sores.
If you experience any side effects while using Efudex cream consult with your doctor on ways manage the side effects. Contact your doctor for more medical treatment if any serious side effects occur.